Heterogeneity of Memory Marginal Zone B Cells

Human blood IgM " memory " B cells are circulating splenic marginal zone B cells

The human peripheral B cell compartment displays a large population of IgM IgD CD27 memory B cell carrying a mutated Ig + + + “ ” receptor. We show here, by phenotypic analysis, CDR3 spectratyping during a T-independent response and gene expression profiling of the different blood and splenic B cell subsets, that blood IgM IgD CD27 cells correspond to circulating splenic marginal zone B cells. ...

Capture by Marginal Zone Macrophages Marginal Zone B Cells Regulate Antigen

Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone

Specialized B cells residing in the splenic marginal zone (MZ) continuously survey the blood for antigens and are important for immunity to systemic infections. However, the cues that uniquely attract cells to the MZ have not been defined. Previous work demonstrated that mice deficient in cannabinoid receptor 2 (CB2) have decreased numbers of MZ B cells but it has been unclear whether CB2 regul...

gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells.

The rapid Ab responses observed after primary and secondary immunizations are mainly derived from marginal zone (MZ) and memory B cells, respectively, but it is largely unknown how these responses are negatively regulated. Several inhibitory receptors have been identified and their roles have been studied, but mainly on follicular B cells and much less so on MZ B, and never on memory B cells. g...

Marginal Zone B-cell lymphoma

Extra-nodal MZBCL of MALT type (7% of all NHL) is an indolent disease involving most often the stomach, where it usually follows chronic gastritis due to Helicobacter pylori (HP) infection. The disease may also localize in the lung, the thyroid, the salivary gland, the orbit. Splenic MZBCL (1% of all NHL on histologic samples) usually, though not invariably, presents splenomegaly associated cir...